|Other Names||cAMP-specific 3', 5'-cyclic phosphodiesterase 4C, DPDE1, PDE21, PDE4C, DPDE1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.|
|Cellular Location||Cell projection, cilium.|
|Tissue Location||Expressed in various tissues but not in cells of the immune system|
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Provided below are standard protocols that you may find useful for product applications.
Cyclic nucleotides are important second messengers thatregulate and mediate a number of cellular responses toextracellular signals, such as hormones, light, andneurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs)regulate the cellular concentrations of cyclic nucleotides andthereby play a role in signal transduction. PDE4C is a class IVcAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed8009369]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Sullivan, M., et al. Cell. Signal. 11(10):735-742(1999)
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