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PDE4C Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q08493 |
|---|---|
| Clone Names | 110819082 |
| Gene ID | 5143 |
|---|---|
| Other Names | cAMP-specific 3', 5'-cyclic phosphodiesterase 4C, DPDE1, PDE21, PDE4C, DPDE1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PDE4C (HGNC:8782) |
|---|---|
| Synonyms | DPDE1 |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
| Cellular Location | Cell projection, cilium {ECO:0000250|UniProtKB:Q3UEI1} |
| Tissue Location | Expressed in various tissues but not in cells of the immune system. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cyclic nucleotides are important second messengers thatregulate and mediate a number of cellular responses toextracellular signals, such as hormones, light, andneurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs)regulate the cellular concentrations of cyclic nucleotides andthereby play a role in signal transduction. PDE4C is a class IVcAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed8009369]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Sullivan, M., et al. Cell. Signal. 11(10):735-742(1999)
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