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SLC4A8 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q2Y0W8
Clone Names 110819093
Peptide ID 110819093
Additional Information
Gene ID 9498
Other Names Electroneutral sodium bicarbonate exchanger 1, Electroneutral Na(+)-driven Cl-HCO3 exchanger, Solute carrier family 4 member 8, k-NBC3, S4A8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name S4A8
Function Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex
Research Areas
Citations (0)

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Background

SLC4A8 mediates electroneutral sodium-and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.

References

Parker, M.D., et al. Physiol. Genomics 34(3):265-276(2008)Loiselle, F.B., et al. Am. J. Physiol., Cell Physiol. 286 (6), C1423-C1433 (2004) :Pushkin, A., et al. Am. J. Physiol., Cell Physiol. 284 (3), C667-C673 (2003) :Park, M., et al. J. Biol. Chem. 277(52):50503-50509(2002)Gresz, V., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 283 (2), G473-G480 (2002) :

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$ 80.00
Cat# BP18549a
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