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SLC4A8 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q2Y0W8 |
|---|---|
| Clone Names | 110819093 |
| Gene ID | 9498 |
|---|---|
| Other Names | Electroneutral sodium bicarbonate exchanger 1, Electroneutral Na(+)-driven Cl-HCO3 exchanger, Solute carrier family 4 member 8, k-NBC3, S4A8 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC4A8 {ECO:0000312|EMBL:AAY79176.1, ECO:0000312|HGNC:HGNC:11034} |
|---|---|
| Function | Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:18577713). Plays a major role in pH regulation in neurons (By similarity). Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q6RVG2}; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q6RVG2}; Multi-pass membrane protein [Isoform 3]: Cell membrane; Multi-pass membrane protein [Isoform 5]: Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. [Isoform 4]: Expressed in the brain, heart and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC4A8 mediates electroneutral sodium-and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.
References
Parker, M.D., et al. Physiol. Genomics 34(3):265-276(2008)Loiselle, F.B., et al. Am. J. Physiol., Cell Physiol. 286 (6), C1423-C1433 (2004) :Pushkin, A., et al. Am. J. Physiol., Cell Physiol. 284 (3), C667-C673 (2003) :Park, M., et al. J. Biol. Chem. 277(52):50503-50509(2002)Gresz, V., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 283 (2), G473-G480 (2002) :
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