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GNAS Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O95467
Clone Names 110826163
Peptide ID 110826163
Additional Information
Gene ID 2778
Other Names Neuroendocrine secretory protein 55, NESP55, LHAL tetrapeptide, GPIPIRRH peptide, GNAS (HGNC:4392)
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GNAS (HGNC:4392)
Cellular Location Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Neuroendocrine secretory granules.
Research Areas
Citations (0)

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This locus has a highly complex imprinted expressionpattern. It gives rise to maternally, paternally, and biallelicallyexpressed transcripts that are derived from four alternativepromoters and 5' exons. Some transcripts contains a differentiallymethylated region (DMR) at their 5' exons, and this DMR is commonlyfound in imprinted genes and correlates with transcript expression.An antisense transcript is produced from an overlapping locus onthe opposite strand. One of the transcripts produced from thislocus, and the antisense transcript, are paternally expressednoncoding RNAs, and may regulate imprinting in this region. Inaddition, one of the transcripts contains a second overlapping ORF,which encodes a structurally unrelated protein - Alex. Alternativesplicing of downstream exons is also observed, which results indifferent forms of the stimulatory G-protein alpha subunit, a keyelement of the classical signal transduction pathway linkingreceptor-ligand interactions with the activation of adenylylcyclase and a variety of cellular reponses. Multiple transcriptvariants encoding different isoforms have been found for this gene.Mutations in this gene result in pseudohypoparathyroidism type 1a,pseudohypoparathyroidism type 1b, Albright hereditaryosteodystrophy, pseudopseudohypoparathyroidism, McCune-Albrightsyndrome, progressive osseus heteroplasia, polyostotic fibrousdysplasia of bone, and some pituitary tumors.


Idziaszczyk, S., et al. Cancer Genet. Cytogenet. 202(1):67-69(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Tominaga, E., et al. Gynecol. Oncol. 118(2):160-166(2010)Park, C.H., et al. Ann. Clin. Lab. Sci. 40(3):261-266(2010)Cross, D.S., et al. BMC Genet. 11, 51 (2010) :

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$ 80.00
Cat# BP18552b
Availability: In Stock
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