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HBS1L Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y450
Clone Names 110826182
Additional Information
Gene ID 10767
Other Names HBS1-like protein, ERFS, HBS1L, HBS1, KIAA1038
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HBS1L {ECO:0000303|PubMed:28204585, ECO:0000312|HGNC:HGNC:4834}
Function GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463).
Cellular Location Cytoplasm.
Tissue Location Detected in heart, brain, placenta, liver, muscle, kidney and pancreas.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the GTP-binding elongationfactor family. It is expressed in multiple tissues with the highestexpression in heart and skeletal muscle. The intergenic region ofthis gene and the MYB gene has been identified to be a quantitativetrait locus (QTL) controlling fetal hemoglobin level, and thisregion influnces erythrocyte, platelet, and monocyte counts as wellas erythrocyte volume and hemoglobin content. DNA polymorphisms atthis region associate with fetal hemoglobin levels and pain crisesin sickle cell disease. A single nucleotide polymorphism in exon 1of this gene is significantly associated with severity inbeta-thalassemia/Hemoglobin E. Multiple alternatively splicedtranscript variants encoding different protein isoforms have beenfound for this gene.

References

Nuinoon, M., et al. Hum. Genet. 127(3):303-314(2010)Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Nuinoon, M., et al. Hum. Genet. (2009) In press :Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)Ferreira, M.A., et al. Am. J. Hum. Genet. 85(5):745-749(2009)

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$ 277.78
Cat# BP18556c
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