|Other Names||HIRA-interacting protein 3, HIRIP3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.|
|Cellular Location||Nucleus. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis|
|Tissue Location||Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart|
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The HIRA protein shares sequence similarity with Hir1pand Hir2p, the two corepressors of histone gene transcriptioncharacterized in the yeast, Saccharomyces cerevisiae. Thestructural features of the HIRA protein suggest that it mayfunction as part of a multiprotein complex. Recently, severalcDNAs encoding HIRA-interacting proteins, or HIRIPs, have beenidentified. In vitro, the HIRIP3 gene product binds HIRA, as wellas H2B and H3 core histones, indicating that a complex containingHIRA-HIRIP3 could function in some aspects of chromatin and histonemetabolism.
Kumar, R.A., et al. PLoS ONE 4 (2), E4582 (2009) :Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Assrir, N., et al. Biol. Chem. 388(4):391-398(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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