|Other Names||HORMA domain-containing protein 1, Cancer/testis antigen 46, CT46, Newborn ovary HORMA protein, HORMAD1, NOHMA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity).|
|Cellular Location||Nucleus. Chromosome. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity)|
|Tissue Location||Testis-specific. Over-expressed in carcinomas.|
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Provided below are standard protocols that you may find useful for product applications.
HORMAD1 may monitor and regulate pairing, synapsis, or recombination between homologous chromosomes during meiosis (By similarity).
Chen, Y.T., et al. Cancer Immun. 5, 9 (2005) :Pangas, S.A., et al. Gene Expr. Patterns 5(2):257-263(2004)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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