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HORMAD1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86X24
Clone Names 110717073
Peptide ID 110717073
Additional Information
Gene ID 84072
Other Names HORMA domain-containing protein 1, Cancer/testis antigen 46, CT46, Newborn ovary HORMA protein, HORMAD1, NOHMA
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HORMAD1 (HGNC:25245)
Function Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q9D5T7}. Chromosome {ECO:0000250|UniProtKB:Q9D5T7}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity). {ECO:0000250|UniProtKB:Q9D5T7}
Tissue Location Testis-specific. Over-expressed in carcinomas.
Research Areas
Citations (0)

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Background

HORMAD1 may monitor and regulate pairing, synapsis, or recombination between homologous chromosomes during meiosis (By similarity).

References

Chen, Y.T., et al. Cancer Immun. 5, 9 (2005) :Pangas, S.A., et al. Gene Expr. Patterns 5(2):257-263(2004)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)

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$ 80.00
Cat# BP18581c
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