|Other Names||Lymphocyte transmembrane adapter 1, Linker for activation of X cells, Membrane-associated adapter protein LAX, LAX1, LAX|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein|
|Tissue Location||Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
LAX1 negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)Shapiro, M.J., et al. J. Immunol. 181(10):7055-7061(2008)Zhu, M., et al. J. Immunol. 174(9):5612-5619(2005)Zhu, M., et al. J. Biol. Chem. 277(48):46151-46158(2002)
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