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Mouse Dcdc2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q5DU00 |
|---|---|
| Clone Names | 110819125 |
| Gene ID | 195208 |
|---|---|
| Other Names | Doublecortin domain-containing protein 2, Dcdc2, Dcdc2a, Kiaa1154 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Dcdc2 |
|---|---|
| Synonyms | Dcdc2a, Kiaa1154 |
| Function | Protein that plays a role in the inhibition of canonical Wnt signaling pathway (By similarity). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (By similarity). |
| Cellular Location | Cell projection, cilium {ECO:0000250|UniProtKB:Q9UHG0}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9UHG0}. Cell projection, kinocilium {ECO:0000250|UniProtKB:D3ZR10}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:D3ZR10}. Note=Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner {ECO:0000250|UniProtKB:Q9UHG0} |
| Tissue Location | Expressed in hair cells of the inner ear. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the doublecortin family. Theprotein encoded by this gene contains two doublecortin domains. Thedoublecortin domain has been demonstrated to bind tubulin andenhance microtubule polymerization. Alternatively splicedtranscript variants encoding distinct isoforms have been found forthis gene.
References
Dijkmans, T.F., et al. Cent Nerv Syst Agents Med Chem 10(1):32-46(2010)Coquelle, F.M., et al. Cell Cycle 5(9):976-983(2006)Reiner, O., et al. BMC Genomics 7, 188 (2006) :
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