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SURF4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O15260 |
|---|---|
| Clone Names | 110819101 |
| Gene ID | 6836 |
|---|---|
| Other Names | Surfeit locus protein 4, SURF4, SURF-4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SURF4 {ECO:0000303|PubMed:18287528, ECO:0000312|HGNC:HGNC:11476} |
|---|---|
| Function | Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed:30251625, PubMed:29643117, PubMed:33186557). Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed:29643117, PubMed:33186557). Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins (PubMed:33186557). Promotes the secretion of PCSK9 (PubMed:30251625). Also mediates the efficient secretion of erythropoietin (EPO) (PubMed:32989016). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi (PubMed:18287528). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi- pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is located in the surfeit gene cluster, which iscomprised of very tightly linked housekeeping genes that do notshare sequence similarity. The encoded protein is a conservedintegral membrane protein containing multiple putativetransmembrane regions. In eukaryotic cells, protein transportbetween the endoplasmic reticulum and Golgi compartments ismediated in part by non-clathrin-coated vesicular coat proteins(COPs). The specific function of this protein has not beendetermined but its yeast homolog is directly required for packagingglycosylated pro-alpha-factor into COPII vesicles. This gene usesmultiple polyadenylation sites, resulting in transcript lengthvariation. The existence of alternatively spliced transcriptvariants has been suggested, but their validity has not beendetermined.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Mitrovic, S., et al. Mol. Biol. Cell 19(5):1976-1990(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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