|Other Names||Surfeit locus protein 4, SURF4, SURF-4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.|
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This gene is located in the surfeit gene cluster, which iscomprised of very tightly linked housekeeping genes that do notshare sequence similarity. The encoded protein is a conservedintegral membrane protein containing multiple putativetransmembrane regions. In eukaryotic cells, protein transportbetween the endoplasmic reticulum and Golgi compartments ismediated in part by non-clathrin-coated vesicular coat proteins(COPs). The specific function of this protein has not beendetermined but its yeast homolog is directly required for packagingglycosylated pro-alpha-factor into COPII vesicles. This gene usesmultiple polyadenylation sites, resulting in transcript lengthvariation. The existence of alternatively spliced transcriptvariants has been suggested, but their validity has not beendetermined.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Mitrovic, S., et al. Mol. Biol. Cell 19(5):1976-1990(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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