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CLCF1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UBD9
Clone Names 110826081
Peptide ID 110826081
Additional Information
Gene ID 23529
Other Names Cardiotrophin-like cytokine factor 1, B-cell-stimulating factor 3, BSF-3, Novel neurotrophin-1, NNT-1, CLCF1, BSF3, CLC, NNT1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLCF1
Synonyms BSF3, CLC, NNT1
Function Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.
Cellular Location Secreted.
Tissue Location Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
Research Areas
Citations (0)

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This gene is a member of the glycoprotein (gp)130 cytokinefamily and encodes cardiotrophin-like cytokine factor 1 (CLCF1).CLCF1 forms a heterodimer complex with cytokine receptor-likefactor 1 (CRLF1). This dimer competes with ciliary neurotrophicfactor (CNTF) for binding to the ciliary neurotrophic factorreceptor (CNTFR) complex, and activates the Jak-STAT signalingcascade. CLCF1 can be actively secreted from cells by forming acomplex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is apotent neurotrophic factor, B-cell stimulatory agent andneuroendocrine modulator of pituitary corticotroph function.Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2).This syndrome is characterized by a profuse sweating after exposureto cold as well as congenital physical abnormalities of the headand spine. Alternative splicing results in multiple transcriptvariants encoding distinct isoforms.


Rousseau, F., et al. J. Biol. Chem. 283(44):30341-30350(2008)Dagoneau, N., et al. Am. J. Hum. Genet. 80(5):966-970(2007)Rousseau, F., et al. Proc. Natl. Acad. Sci. U.S.A. 103(26):10068-10073(2006)Perret, D., et al. J. Biol. Chem. 279(42):43961-43970(2004)Burger, R., et al. Br. J. Haematol. 123(5):869-878(2003)

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$ 80.00
Cat# BP18774a
Availability: In Stock
Bulk Size
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