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CLCF1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UBD9 |
|---|---|
| Clone Names | 110826081 |
| Gene ID | 23529 |
|---|---|
| Other Names | Cardiotrophin-like cytokine factor 1, B-cell-stimulating factor 3, BSF-3, Novel neurotrophin-1, NNT-1, CLCF1, BSF3, CLC, NNT1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLCF1 |
|---|---|
| Synonyms | BSF3, CLC, NNT1 |
| Function | In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the glycoprotein (gp)130 cytokinefamily and encodes cardiotrophin-like cytokine factor 1 (CLCF1).CLCF1 forms a heterodimer complex with cytokine receptor-likefactor 1 (CRLF1). This dimer competes with ciliary neurotrophicfactor (CNTF) for binding to the ciliary neurotrophic factorreceptor (CNTFR) complex, and activates the Jak-STAT signalingcascade. CLCF1 can be actively secreted from cells by forming acomplex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is apotent neurotrophic factor, B-cell stimulatory agent andneuroendocrine modulator of pituitary corticotroph function.Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2).This syndrome is characterized by a profuse sweating after exposureto cold as well as congenital physical abnormalities of the headand spine. Alternative splicing results in multiple transcriptvariants encoding distinct isoforms.
References
Rousseau, F., et al. J. Biol. Chem. 283(44):30341-30350(2008)Dagoneau, N., et al. Am. J. Hum. Genet. 80(5):966-970(2007)Rousseau, F., et al. Proc. Natl. Acad. Sci. U.S.A. 103(26):10068-10073(2006)Perret, D., et al. J. Biol. Chem. 279(42):43961-43970(2004)Burger, R., et al. Br. J. Haematol. 123(5):869-878(2003)
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