|Other Names||ATP-dependent RNA helicase DHX36, DEAH box protein 36, G4-resolvase 1, G4R1, MLE-like protein 1, RNA helicase associated with AU-rich element ARE, DHX36, DDX36, KIAA1488, MLEL1, RHAU|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DDX36, KIAA1488, MLEL1, RHAU|
|Function||Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.|
|Cellular Location||Nucleus. Cytoplasm. Chromosome, telomere. Note=Isoform 1 preferentially localized to the nucleus and isoform 2 localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli. Localizes to cytoplasmic stress granules|
|Tissue Location||Highly expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the DEAH-box family ofRNA-dependent NTPases which are named after the conserved aminoacid sequence Asp-Glu-Ala-His in motif II. The protein encoded bythis gene has been shown to enhance the deadenylation and decay ofmRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has alsobeen shown to resolve into single strands the highly stabletetramolecular DNA configuration (G4) that can form spontaneouslyin guanine-rich regions of DNA. Alternative splicing results inmultiple transcript variants encoding different isoforms. [providedby RefSeq].
Lattmann, S., et al. Nucleic Acids Res. 38(18):6219-6233(2010)Kim, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15181-15186(2010)Chalupnikova, K., et al. J. Biol. Chem. 283(50):35186-35198(2008)Creacy, S.D., et al. J. Biol. Chem. 283(50):34626-34634(2008)Iwamoto, F., et al. Exp. Cell Res. 314(6):1378-1391(2008)
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