|Other Names||14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.|
|Cellular Location||Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway|
|Tissue Location||Present mainly in tissues enriched in stratified squamous keratinizing epithelium|
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Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity).p53-regulated inhibitor of G2/M progression.
Ren, H.Z., et al. Dig. Dis. Sci. 55(9):2552-2560(2010)Liu, Y., et al. Brain Res. 1336, 98-102 (2010) :Pei, H.P., et al. Zhonghua Wei Chang Wai Ke Za Zhi 13(3):213-215(2010)Syrjanen, S., et al. Am. J. Clin. Pathol. 133(2):232-240(2010)Zurita, M., et al. BMC Cancer 10, 217 (2010) :
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