|Other Names||Voltage-dependent anion-selective channel protein 2, VDAC-2, hVDAC2, Outer mitochondrial membrane protein porin 2, VDAC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective.|
|Cellular Location||Mitochondrion outer membrane|
|Tissue Location||Expressed in all tissues examined.|
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This gene encodes a member of the voltage-dependent anionchannel pore-forming family of proteins that are considered themain pathway for metabolite diffusion across the mitochondrialouter membrane. The encoded protein is also thought to be involvedin the mitochondrial apoptotic pathway via regulation ofBCL2-antagonist/killer 1 protein activity. Pseudogenes have beenidentified on chromosomes 1, 2, 12 and 21, and alternative splicingresults in multiple transcript variants.
De Pinto, V., et al. Biochim. Biophys. Acta 1797 (6-7), 1268-1275 (2010) :Liu, B., et al. Biochem. Biophys. Res. Commun. 378(3):366-370(2009)Valis, K., et al. Mol. Cell. Biochem. 311 (1-2), 225-231 (2008) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Yoo, B.C., et al. Electrophoresis 22(1):172-179(2001)
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