|Other Names||Neurabin-1, Neurabin-I, Neural tissue-specific F-actin-binding protein I, Protein phosphatase 1 regulatory subunit 9A, PPP1R9A, KIAA1222|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to actin filaments (F-actin) and shows cross- linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1- alpha activity (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, synapse, synaptosome|
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This gene is imprinted, and located in a cluster ofimprinted genes on chromosome 7q12. This gene is transcribed inboth neuronal and multiple embryonic tissues, and it is maternallyexpressed mainly in embryonic skeletal muscle tissues andbiallelically expressed in other embryonic tissues. The proteinencoded by this gene includes a PDZ domain and a sterile alphamotif (SAM). It is a regulatory subunit of protein phosphatase I,and controls actin cytoskeleton reorganization. Alternativelyspliced transcript variants encoding different isoforms have beenfound for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Suarez-Gestal, M., et al. Arthritis Res. Ther. 12 (2), R72 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Nakabayashi, K., et al. J. Med. Genet. 41(8):601-608(2004)
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