SKAP1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q86WV1 |
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Clone Names | 100517106 |
Gene ID | 8631 |
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Other Names | Src kinase-associated phosphoprotein 1, Src family-associated phosphoprotein 1, Src kinase-associated phosphoprotein of 55 kDa, SKAP-55, pp55, SKAP1, SCAP1, SKAP55 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SKAP1 |
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Synonyms | SCAP1, SKAP55 |
Function | Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T- cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. |
Cellular Location | Cytoplasm. Nucleus. Cell membrane. Note=Upon T- cell stimulation, translocates to lipid rafts at the cell membrane |
Tissue Location | Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T- cells (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a T cell adaptor protein, a class ofintracellular molecules with modular domains capable of recruitingadditional proteins but that exhibit no intrinsic enzymaticactivity. The encoded protein contains a unique N-terminal regionfollowed by a PH domain and C-terminal SH3 domain. Along with theadhesion and degranulation-promoting adaptor protein, the encodedprotein plays a critical role in inside-out signaling by couplingT-cell antigen receptor stimulation to the activation of integrins.
References
Goode, E.L., et al. Nat. Genet. 42(10):874-879(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Raab, M., et al. Immunity 32(4):541-556(2010)Lehmann, R., et al. Proteomics 9(23):5288-5295(2009)Fang, L., et al. Cell Cycle 8(17):2819-2827(2009)
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