|Other Names||Fructose-bisphosphate aldolase B, Liver-type aldolase, ALDOB, ALDB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite|
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Fructose-1,6-bisphosphate aldolase (EC 184.108.40.206) is atetrameric glycolytic enzyme that catalyzes the reversibleconversion of fructose-1,6-bisphosphate to glyceraldehyde3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3aldolase isozymes which are distinguished by their electrophoreticand catalytic properties. Differences indicate that aldolases A, B,and C are distinct proteins, the products of a family of related'housekeeping' genes exhibiting developmentally regulatedexpression of the different isozymes. The developing embryoproduces aldolase A, which is produced in even greater amounts inadult muscle where it can be as much as 5% of total cellularprotein. In adult liver, kidney and intestine, aldolase Aexpression is repressed and aldolase B is produced. In brain andother nervous tissue, aldolase A and C are expressed about equally.There is a high degree of homology between aldolase A and C.Defects in ALDOB cause hereditary fructose intolerance. [providedby RefSeq].
Bouteldja, N., et al. J. Inherit. Metab. Dis. 33(2):105-112(2010)Coffee, E.M., et al. J. Inherit. Metab. Dis. 33(1):33-42(2010)Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)Davit-Spraul, A., et al. Mol. Genet. Metab. 94(4):443-447(2008)Eriksson, A., et al. BMC Gastroenterol 8, 34 (2008) :
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