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ALDOB Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P05062 |
|---|---|
| Clone Names | 100617307 |
| Gene ID | 229 |
|---|---|
| Other Names | Fructose-bisphosphate aldolase B, Liver-type aldolase, ALDOB, ALDB |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ALDOB {ECO:0000303|PubMed:15880727, ECO:0000312|HGNC:HGNC:417} |
|---|---|
| Function | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D- glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). |
| Cellular Location | Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite |
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Provided below are standard protocols that you may find useful for product applications.
Background
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is atetrameric glycolytic enzyme that catalyzes the reversibleconversion of fructose-1,6-bisphosphate to glyceraldehyde3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3aldolase isozymes which are distinguished by their electrophoreticand catalytic properties. Differences indicate that aldolases A, B,and C are distinct proteins, the products of a family of related'housekeeping' genes exhibiting developmentally regulatedexpression of the different isozymes. The developing embryoproduces aldolase A, which is produced in even greater amounts inadult muscle where it can be as much as 5% of total cellularprotein. In adult liver, kidney and intestine, aldolase Aexpression is repressed and aldolase B is produced. In brain andother nervous tissue, aldolase A and C are expressed about equally.There is a high degree of homology between aldolase A and C.Defects in ALDOB cause hereditary fructose intolerance. [providedby RefSeq].
References
Bouteldja, N., et al. J. Inherit. Metab. Dis. 33(2):105-112(2010)Coffee, E.M., et al. J. Inherit. Metab. Dis. 33(1):33-42(2010)Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)Davit-Spraul, A., et al. Mol. Genet. Metab. 94(4):443-447(2008)Eriksson, A., et al. BMC Gastroenterol 8, 34 (2008) :
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