|Other Names||Plastin-2, L-plastin, LC64P, Lymphocyte cytosolic protein 1, LCP-1, LCP1, PLS2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction. Cell projection. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28. Associated with the actin cytoskeleton at membrane ruffles (By similarity). Relocalizes to actin-rich cell projections upon serine phosphorylation.|
|Tissue Location||Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.|
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Plastins are a family of actin-binding proteins that areconserved throughout eukaryote evolution and expressed in mosttissues of higher eukaryotes. In humans, two ubiquitous plastinisoforms (L and T) have been identified. Plastin 1 (otherwise knownas Fimbrin) is a third distinct plastin isoform which isspecifically expressed at high levels in the small intestine. The Lisoform is expressed only in hemopoietic cell lineages, while the Tisoform has been found in all other normal cells of solid tissuesthat have replicative potential (fibroblasts, endothelial cells,epithelial cells, melanocytes, etc.). However, L-plastin has beenfound in many types of malignant human cells of non-hemopoieticorigin suggesting that its expression is induced accompanyingtumorigenesis in solid tissues.
Wabnitz, G.H., et al. Eur. J. Immunol. 40(9):2437-2449(2010)Janji, B., et al. J. Cell. Mol. Med. 14 (6A), 1264-1275 (2010) :Le Goff, E., et al. Cytoskeleton (Hoboken) 67(5):286-296(2010)Al Tanoury, Z., et al. PLoS ONE 5 (2), E9210 (2010) :Malhotra, A., et al. Diabetes Metab. Res. Rev. 25(8):740-747(2009)
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