|Other Names||MKL/myocardin-like protein 1, Megakaryoblastic leukemia 1 protein, Megakaryocytic acute leukemia protein, Myocardin-related transcription factor A, MRTF-A, MKL1, KIAA1438, MAL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm Note=Binding to globular actin is required to maintain cytoplasmic localization. Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear globular actin, promoting retention of MKL1 in the nucleus and subsequent formation of an active complex with SRF (PubMed:24440334)|
|Tissue Location||Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain|
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The protein encoded by this gene interacts with thetranscription factor myocardin, a key regulator of smooth musclecell differentiation. The encoded protein is predominantly nuclearand may help transduce signals from the cytoskeleton to thenucleus. This gene is involved in a specific translocation eventthat creates a fusion of this gene and the RNA-binding motifprotein-15 gene. This translocation has been associated with acutemegakaryocytic leukemia.
Gilles, L., et al. Blood 114(19):4221-4232(2009)Hinohara, K., et al. Hum. Genet. 126(4):539-547(2009)Estrada, K., et al. Hum. Mol. Genet. 18(18):3516-3524(2009)Brandt, D.T., et al. Nat. Cell Biol. 11(5):557-568(2009)Medjkane, S., et al. Nat. Cell Biol. 11(3):257-268(2009)
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