|Other Names||Osteoclast-associated immunoglobulin-like receptor, Osteoclast-associated receptor, hOSCAR, Polymeric immunoglobulin receptor 3, PIgR-3, PIgR3, Poly-Ig receptor 3, OSCAR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.|
|Cellular Location||Isoform 1: Secreted.|
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Osteoclasts are multinucleated cells that resorb bone andare essential for bone homeostasis. This gene encodes anosteoclast-associated receptor (OSCAR), which is a member of theleukocyte receptor complex (LRC) protein family that plays criticalroles in the regulation of both innate and adaptive immuneresponses. Different from the other LRC members, OSCAR expressionis detected specifically in preosteoclasts or mature osteoclasts.OSCAR may be an important bone-specific regulator of osteoclastdifferentiation. Multiple alternatively spliced transcript variantsencoding different isoforms have been found for this gene.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Herman, S., et al. Arthritis Rheum. 58(10):3041-3050(2008)Merck, E., et al. J. Immunol. 176(5):3149-3156(2006)Kim, K., et al. J. Biol. Chem. 280(42):35209-35216(2005)
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