|Other Names||Pleckstrin homology-like domain family A member 1, Apoptosis-associated nuclear protein, Proline- and glutamine-rich protein, PQ-rich protein, PQR protein, Proline- and histidine-rich protein, T-cell death-associated gene 51 protein, PHLDA1, PHRIP, TDAG51|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle. Nucleus, nucleolus. Note=Colocalizes with intracellular vesicles.|
|Tissue Location||Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).|
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This gene encodes an evolutionarily conservedproline-histidine rich nuclear protein. The encoded protein mayplay an important role in the anti-apoptotic effects ofinsulin-like growth factor-1.
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Marchiori, A.C., et al. Braz. J. Med. Biol. Res. 41(7):579-582(2008)Nagai, M.A., et al. Breast Cancer Res. Treat. 106(1):49-56(2007)Xi, Z.Q., et al. Neurosci. Lett. 425(1):53-58(2007)Meier-Noorden, M., et al. Gene 338(2):197-207(2004)
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