|Other Names||G2/M phase-specific E3 ubiquitin-protein ligase, 632-, G2E3, KIAA1333|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.|
|Cellular Location||Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage|
|Tissue Location||Predominantly expressed in brain, liver, kidney, testes and ovary.|
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E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
Brooks, W.S., et al. J. Biol. Chem. 283(32):22304-22315(2008)Brooks, W.S., et al. Exp. Cell Res. 313(4):665-676(2007)Lehner, B., et al. Genomics 83(1):153-167(2004)Crawford, D.F., et al. J. Biol. Chem. 276(40):37166-37177(2001)
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