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G2E3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q7L622 |
|---|---|
| Clone Names | 110826137 |
| Gene ID | 55632 |
|---|---|
| Other Names | G2/M phase-specific E3 ubiquitin-protein ligase, 632-, G2E3, KIAA1333 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | G2E3 |
|---|---|
| Synonyms | KIAA1333 |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death. |
| Cellular Location | Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage |
| Tissue Location | Predominantly expressed in brain, liver, kidney, testes and ovary. |
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
References
Brooks, W.S., et al. J. Biol. Chem. 283(32):22304-22315(2008)Brooks, W.S., et al. Exp. Cell Res. 313(4):665-676(2007)Lehner, B., et al. Genomics 83(1):153-167(2004)Crawford, D.F., et al. J. Biol. Chem. 276(40):37166-37177(2001)
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