ITPA Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BY32 |
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Clone Names | 100311246 |
Gene ID | 3704 |
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Other Names | Inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, ITPase {ECO:0000255|HAMAP-Rule:MF_03148}, Inosine triphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, 36119 {ECO:0000255|HAMAP-Rule:MF_03148}, Non-canonical purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, Non-standard purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, Nucleoside-triphosphate diphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, Nucleoside-triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, NTPase {ECO:0000255|HAMAP-Rule:MF_03148}, Putative oncogene protein hlc14-06-p, ITPA {ECO:0000255|HAMAP-Rule:MF_03148}, C20orf37 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ITPA {ECO:0000255|HAMAP-Rule:MF_03148} |
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Synonyms | C20orf37 |
Function | Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. |
Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832} |
Tissue Location | Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene hydrolyzes inosinetriphosphate and deoxyinosine triphosphate to the monophosphatenucleotide and diphosphate. The encoded protein, which is a memberof the HAM1 NTPase protein family, is found in the cytoplasm andacts as a homodimer. Defects in the encoded protein can result ininosine triphosphate pyrophosphorylase deficiency. Two transcriptvariants encoding two different isoforms have been found for thisgene. Also, at least two other transcript variants have beenidentified which are probably regulatory rather thanprotein-coding.
References
Kim, J.H., et al. J. Clin. Gastroenterol. 44 (10), E242-E248 (2010) :Ochi, H., et al. Gastroenterology 139(4):1190-1197(2010)Thompson, A.J., et al. Gastroenterology 139(4):1181-1189(2010)Ban, H., et al. J. Gastroenterol. 45(10):1014-1021(2010)Fellay, J., et al. Nature 464(7287):405-408(2010)
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