|Other Names||Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, DMP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.|
|Cellular Location||Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus|
|Tissue Location||Expressed in tooth particularly in odontoblast, ameloblast and cementoblast|
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Dentin matrix acidic phosphoprotein is an extracellularmatrix protein and a member of the small integrin binding ligandN-linked glycoprotein family. This protein, which is critical forproper mineralization of bone and dentin, is present in diversecells of bone and tooth tissues. The protein contains a largenumber of acidic domains, multiple phosphorylation sites, afunctional arg-gly-asp cell attachment sequence, and a DNA bindingdomain. In undifferentiated osteoblasts it is primarily a nuclearprotein that regulates the expression of osteoblast-specific genes.During osteoblast maturation the protein becomes phosphorylated andis exported to the extracellular matrix, where it orchestratesmineralized matrix formation. Mutations in the gene are known tocause autosomal recessive hypophosphatemia, a disease thatmanifests as rickets and osteomalacia. The gene structure isconserved in mammals. Two transcript variants encoding differentisoforms have been described for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Turan, S., et al. Bone 46(2):402-409(2010)Pereira, R.C., et al. Bone 45(6):1161-1168(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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