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PTCRA Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6ISU1 |
|---|---|
| Clone Names | 100324288 |
| Gene ID | 171558 |
|---|---|
| Other Names | Pre T-cell antigen receptor alpha, pT-alpha, pTa, pT-alpha-TCR, PTCRA |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PTCRA |
|---|---|
| Function | The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
In immature T cells the T-cell receptor beta-chain gene(TCRB; MIM 186930) is rearranged and expressed before the TCRA (MIM186880) chain. At this early stage, TCRB can associate with thepre-T-cell receptor alpha chain (PTCRA). The PTCRA, together withTCRB and the CD3 complex (see MIM 186740), minimally make up thepre-T cell receptor (pre-TCR), which regulates early T celldevelopment.
References
Velez, D.R., et al. Am. J. Obstet. Gynecol. 200 (2), 209 (2009) :Menon, R., et al. Reprod. Biol. Endocrinol. 7, 62 (2009) :Velez, D.R., et al. PLoS ONE 3 (9), E3283 (2008) :Navarro, M.N., et al. Blood 110(13):4331-4340(2007)Bas, A., et al. J. Immunol. 171(7):3359-3371(2003)
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