|Other Names||Pre T-cell antigen receptor alpha, pT-alpha, pTa, pT-alpha-TCR, PTCRA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow|
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Provided below are standard protocols that you may find useful for product applications.
In immature T cells the T-cell receptor beta-chain gene(TCRB; MIM 186930) is rearranged and expressed before the TCRA (MIM186880) chain. At this early stage, TCRB can associate with thepre-T-cell receptor alpha chain (PTCRA). The PTCRA, together withTCRB and the CD3 complex (see MIM 186740), minimally make up thepre-T cell receptor (pre-TCR), which regulates early T celldevelopment.
Velez, D.R., et al. Am. J. Obstet. Gynecol. 200 (2), 209 (2009) :Menon, R., et al. Reprod. Biol. Endocrinol. 7, 62 (2009) :Velez, D.R., et al. PLoS ONE 3 (9), E3283 (2008) :Navarro, M.N., et al. Blood 110(13):4331-4340(2007)Bas, A., et al. J. Immunol. 171(7):3359-3371(2003)
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