|Other Names||Cation channel sperm-associated protein 2, CatSper2, CATSPER2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.|
|Cellular Location||Cell projection, cilium, flagellum membrane; Multi-pass membrane protein Note=Specifically located in the principal piece of sperm tail|
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Provided below are standard protocols that you may find useful for product applications.
Calcium ions play a primary role in the regulation ofsperm motility. This gene belongs to a family of putative cationchannels that are specific to spermatozoa and localize to theflagellum. The protein family features a single repeat with sixmembrane-spanning segments and a predicted calcium-selective poreregion. This gene is part of a tandem repeat on chromosome 15q15;the second copy of this gene is thought to be a pseudogene.Additional splice variants have been described but theirfull-length nature has not been determined.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Zhang, D., et al. J. Biol. Chem. 281(31):22332-22341(2006)Clapham, D.E., et al. Pharmacol. Rev. 57(4):451-454(2005)Quill, T.A., et al. Proc. Natl. Acad. Sci. U.S.A. 98(22):12527-12531(2001)
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