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CATSPER2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96P56
Clone Names 100603292
Peptide ID 100603292
Additional Information
Gene ID 117155
Other Names Cation channel sperm-associated protein 2, CatSper2, CATSPER2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Cellular Location Cell projection, cilium, flagellum membrane; Multi-pass membrane protein Note=Specifically located in the principal piece of sperm tail
Tissue Location Testis-specific.
Research Areas
Citations (0)

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Calcium ions play a primary role in the regulation ofsperm motility. This gene belongs to a family of putative cationchannels that are specific to spermatozoa and localize to theflagellum. The protein family features a single repeat with sixmembrane-spanning segments and a predicted calcium-selective poreregion. This gene is part of a tandem repeat on chromosome 15q15;the second copy of this gene is thought to be a pseudogene.Additional splice variants have been described but theirfull-length nature has not been determined.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Zhang, D., et al. J. Biol. Chem. 281(31):22332-22341(2006)Clapham, D.E., et al. Pharmacol. Rev. 57(4):451-454(2005)Quill, T.A., et al. Proc. Natl. Acad. Sci. U.S.A. 98(22):12527-12531(2001)

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$ 80.00
Cat# BP18998b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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