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NR1H4 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96RI1
Clone Names 100430254
Peptide ID 100430254
Additional Information
Gene ID 9971
Other Names Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14, NR1H4, BAR, FXR, HRR1, RIP14
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR1H4
Synonyms BAR, FXR, HRR1, RIP14
Function Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

NR1H4 is a Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.

References

Meyer Zu Schwabedissen, H.E., et al. Hepatology 52(5):1797-1807(2010)Popescu, I.R., et al. FEBS Lett. 584(13):2845-2851(2010)Gadaleta, R.M., et al. Biochim. Biophys. Acta 1801(7):683-692(2010)Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)Erichsen, T.J., et al. J. Hepatol. 52(4):570-578(2010)

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$ 80.00
Cat# BP19002a
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