|Other Names||Adapter protein CIKS, Connection to IKK and SAPK/JNK, Nuclear factor NF-kappa-B activator 1, ACT1, TRAF3-interacting protein 2, TRAF3IP2, C6orf2, C6orf4, C6orf5, C6orf6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C6orf2, C6orf4, C6orf5, C6orf6|
|Function||Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.|
|Tissue Location||Widely expressed.|
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This gene encodes a protein involved in regulatingresponses to cytokines by members of the Rel/NF-kappaBtranscription factor family. These factors play a central role ininnate immunity in response to pathogens, inflammatory signals andstress. This gene product interacts with TRAF proteins (tumornecrosis factor receptor-associated factors) and either I-kappaBkinase or MAP kinase to activate either NF-kappaB or Jun kinase.Several alternative transcripts encoding different isoforms havebeen identified. Another transcript, which does not encode aprotein and is transcribed in the opposite orientation, has beenidentified. Overexpression of this transcript has been shown toreduce expression of at least one of the protein encodingtranscripts, suggesting it has a regulatory role in the expressionof this gene.
Ellinghaus, E., et al. Nat. Genet. 42(11):991-995(2010)Giltiay, N.V., et al. J. Immunol. 185(1):99-109(2010)Liu, C., et al. Sci Signal 2 (92), RA63 (2009) :Li, X. Cytokine 41(2):105-113(2008)Huang, F., et al. J. Immunol. 179(10):6504-6513(2007)
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