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TRAF3IP2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43734 |
|---|---|
| Clone Names | 100427232 |
| Gene ID | 10758 |
|---|---|
| Other Names | Adapter protein CIKS, Connection to IKK and SAPK/JNK, Nuclear factor NF-kappa-B activator 1, ACT1, TRAF3-interacting protein 2, TRAF3IP2, C6orf2, C6orf4, C6orf5, C6orf6 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TRAF3IP2 (HGNC:1343) |
|---|---|
| Function | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). |
| Tissue Location | Widely expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein involved in regulatingresponses to cytokines by members of the Rel/NF-kappaBtranscription factor family. These factors play a central role ininnate immunity in response to pathogens, inflammatory signals andstress. This gene product interacts with TRAF proteins (tumornecrosis factor receptor-associated factors) and either I-kappaBkinase or MAP kinase to activate either NF-kappaB or Jun kinase.Several alternative transcripts encoding different isoforms havebeen identified. Another transcript, which does not encode aprotein and is transcribed in the opposite orientation, has beenidentified. Overexpression of this transcript has been shown toreduce expression of at least one of the protein encodingtranscripts, suggesting it has a regulatory role in the expressionof this gene.
References
Ellinghaus, E., et al. Nat. Genet. 42(11):991-995(2010)Giltiay, N.V., et al. J. Immunol. 185(1):99-109(2010)Liu, C., et al. Sci Signal 2 (92), RA63 (2009) :Li, X. Cytokine 41(2):105-113(2008)Huang, F., et al. J. Immunol. 179(10):6504-6513(2007)
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