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SCUBE3 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8IX30
Clone Names 100406232
Peptide ID 100406232
Additional Information
Gene ID 222663
Other Names Signal peptide, CUB and EGF-like domain-containing protein 3, SCUBE3 (HGNC:13655)
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCUBE3 (HGNC:13655)
Function Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
Cellular Location Secreted. Cell surface
Tissue Location Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells.
Research Areas
Citations (0)

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Background

SCUBE3 contains one CUB domain and 9 EGF-like domains. It is highly expressed in primary osteoblasts and the long bones (humerus and femur) and expression is low or absent in non-bone tissues. It may play an important role in bone cell biology.

References

Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Wu, B.T., et al. J. Biol. Chem. 279(36):37485-37490(2004)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Yang, R.B., et al. J. Biol. Chem. 277(48):46364-46373(2002)

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$ 80.00
Cat# BP19055c
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