|Other Names||Signal peptide, CUB and EGF-like domain-containing protein 3, SCUBE3 (HGNC:13655)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.|
|Cellular Location||Secreted. Cell surface|
|Tissue Location||Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells.|
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Provided below are standard protocols that you may find useful for product applications.
SCUBE3 contains one CUB domain and 9 EGF-like domains. It is highly expressed in primary osteoblasts and the long bones (humerus and femur) and expression is low or absent in non-bone tissues. It may play an important role in bone cell biology.
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Wu, B.T., et al. J. Biol. Chem. 279(36):37485-37490(2004)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Yang, R.B., et al. J. Biol. Chem. 277(48):46364-46373(2002)
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