|Other Names||ATPase WRNIP1, Werner helicase-interacting protein 1, WRNIP1 (HGNC:20876)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.|
|Cellular Location||Nucleus. Note=Colocalizes with WRN in granular structures in the nucleus.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Werner's syndrome is a rare autosomal recessive disordercharacterized by premature aging. The protein encoded by this geneinteracts with the N-terminal portion of Werner protein containingthe exonuclease domain. This protein shows homology to replicationfactor C family proteins, and is conserved from E. coli to human.Studies in yeast suggest that this gene may influence the agingprocess. Two transcript variants encoding different isoforms havebeen isolated for this gene.
Kaur, S., et al. Cell Cycle 9(15):3106-3111(2010)Yoshimura, A., et al. Genes Genet. Syst. 84(2):171-178(2009)Crosetto, N., et al. J. Biol. Chem. 283(50):35173-35185(2008)Mano, Y., et al. Cancer Sci. 98(12):1902-1913(2007)Bish, R.A., et al. J. Biol. Chem. 282(32):23184-23193(2007)
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