|Other Names||ATPase WRNIP1, Werner helicase-interacting protein 1, WRNIP1 (HGNC:20876)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased.|
|Cellular Location||Nucleus. Note=Colocalizes with WRN in granular structures in the nucleus.|
|Tissue Location||Ubiquitously expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Werner's syndrome is a rare autosomal recessive disordercharacterized by premature aging. The protein encoded by this geneinteracts with the N-terminal portion of Werner protein containingthe exonuclease domain. This protein shows homology to replicationfactor C family proteins, and is conserved from E. coli to human.Studies in yeast suggest that this gene may influence the agingprocess. Two transcript variants encoding different isoforms havebeen isolated for this gene.
Kaur, S., et al. Cell Cycle 9(15):3106-3111(2010)Yoshimura, A., et al. Genes Genet. Syst. 84(2):171-178(2009)Crosetto, N., et al. J. Biol. Chem. 283(50):35173-35185(2008)Mano, Y., et al. Cancer Sci. 98(12):1902-1913(2007)Bish, R.A., et al. J. Biol. Chem. 282(32):23184-23193(2007)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.