|Other Names||Integrator complex subunit 12, Int12, PHD finger protein 22, INTS12, PHF22|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1912a was selected from the N-term region of human PHF22. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.|
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Provided below are standard protocols that you may find useful for product applications.
PHF22 is a component of the integrator complex stably associated with RNA polymerase II. The integrator complex mediates RNA polymerase-II-dependent transcription. This protein is recruited to the U1 and U2 snRNA genes and mediates the snRNA's 3' end processing.
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
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