SLC25A20 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O43772 |
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Clone Names | 100318241 |
Gene ID | 788 |
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Other Names | Mitochondrial carnitine/acylcarnitine carrier protein, Carnitine/acylcarnitine translocase, CAC, Solute carrier family 25 member 20, SLC25A20, CAC, CACT |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC25A20 (HGNC:1421) |
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Synonyms | CAC, CACT |
Function | Mediates the electroneutral exchange of acylcarnitines (O- acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)- carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (PubMed:12892634, PubMed:18307102) (Probable). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange) (PubMed:18307102). |
Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene product is one of several closely relatedmitochondrial-membrane carrier proteins that shuttle substratesbetween cytosol and the intramitochondrial matrix space. Thisprotein mediates the transport of acylcarnitines into mitochondrialmatrix for their oxidation by the mitochondrial fattyacid-oxidation pathway. Mutations in this gene are associated withcarnitine-acylcarnitine translocase deficiency, which can cause avariety of pathological conditions such as hypoglycemia, cardiacarrest, hepatomegaly, hepatic dysfunction and muscle weakness, andis usually lethal in new born and infants.
References
Tachibana, K., et al. Biochem. Biophys. Res. Commun. 389(3):501-505(2009)De Lucas, J.R., et al. Mol. Membr. Biol. 25(2):152-163(2008)Pierre, G., et al. J. Inherit. Metab. Dis. 30 (5), 815 (2007) :Peluso, G., et al. J. Cell. Physiol. 203(2):439-446(2005)Kahn, B.B., et al. Cell Metab. 1(1):15-25(2005)
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