|Other Names||Far upstream element-binding protein 3, FUSE-binding protein 3, FUBP3, FBP3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1916b was selected from the N-term region of human FUBP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression.|
|Tissue Location||Detected in a number of cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
The far upstream element-binding proteins FUBP, FUBP2, and FUBP3 comprise a family of single-strand DNA-binding proteins that possess all of the general features of more conventional transcription factors. The FUBPs each bind to a single sequence-specific strand of the far upstream element (FUSE; originally identified upstream of c-myc), and each possesses potent activation domains when fused to the GAL4 DNA-binding domain and assayed by transient transfection. These proteins have also been reported to bind RNA and participate in various steps of RNA processing, transport or catabolism.
He L, et al. Nucleic Acids Res. 2000 Nov 15;28(22):4558-65. Davis-Smyth T, et al. J Biol Chem. 1996 Dec 6;271(49):31679-87.
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