|Other Names||A-kinase anchor protein 5, AKAP-5, A-kinase anchor protein 79 kDa, AKAP 79, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, AKAP5, AKAP79|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.|
|Cellular Location||Membrane; Lipid-anchor. Note=Associates with lipid rafts|
|Tissue Location||Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary|
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The A-kinase anchor proteins (AKAPs) are a group ofstructurally diverse proteins, which have the common function ofbinding to the regulatory subunit of protein kinase A (PKA) andconfining the holoenzyme to discrete locations within the cell.This gene encodes a member of the AKAP family. The encoded proteinbinds to the RII-beta regulatory subunit of PKA, and also toprotein kinase C and the phosphatase calcineurin. It ispredominantly expressed in cerebral cortex and may anchor the PKAprotein at postsynaptic densities (PSD) and be involved in theregulation of postsynaptic events. It is also expressed in Tlymphocytes and may function to inhibit interleukin-2 transcriptionby disrupting calcineurin-dependent dephosphorylation of NFAT.
Willoughby, D., et al. J. Biol. Chem. 285(26):20328-20342(2010)Chen, M.H., et al. Cell. Signal. 21(1):136-142(2009)Tavalin, S.J. J. Biol. Chem. 283(17):11445-11452(2008)Correia, S.S., et al. Nat. Neurosci. 11(4):457-466(2008)Chai, S., et al. J. Biol. Chem. 282(31):22668-22677(2007)
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