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AKAP5 Antibody (Center) Blocking Peptide
Synthetic peptide
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- BACKGROUND
| Primary Accession | P24588 |
|---|---|
| Clone Names | 100623041 |
| Gene ID | 9495 |
|---|---|
| Other Names | A-kinase anchor protein 5, AKAP-5, A-kinase anchor protein 79 kDa, AKAP 79, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, AKAP5, AKAP79 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AKAP5 |
|---|---|
| Synonyms | AKAP79 |
| Function | Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2- adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740). |
| Cellular Location | Postsynaptic recycling endosome membrane; Lipid- anchor. Note=Associates with lipid rafts |
| Tissue Location | Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary |
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Provided below are standard protocols that you may find useful for product applications.
Background
The A-kinase anchor proteins (AKAPs) are a group ofstructurally diverse proteins, which have the common function ofbinding to the regulatory subunit of protein kinase A (PKA) andconfining the holoenzyme to discrete locations within the cell.This gene encodes a member of the AKAP family. The encoded proteinbinds to the RII-beta regulatory subunit of PKA, and also toprotein kinase C and the phosphatase calcineurin. It ispredominantly expressed in cerebral cortex and may anchor the PKAprotein at postsynaptic densities (PSD) and be involved in theregulation of postsynaptic events. It is also expressed in Tlymphocytes and may function to inhibit interleukin-2 transcriptionby disrupting calcineurin-dependent dephosphorylation of NFAT.
References
Willoughby, D., et al. J. Biol. Chem. 285(26):20328-20342(2010)Chen, M.H., et al. Cell. Signal. 21(1):136-142(2009)Tavalin, S.J. J. Biol. Chem. 283(17):11445-11452(2008)Correia, S.S., et al. Nat. Neurosci. 11(4):457-466(2008)Chai, S., et al. J. Biol. Chem. 282(31):22668-22677(2007)
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