|Other Names||Repulsive guidance molecule A, RGM domain family member A, RGMA, RGM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the repulsive guidancemolecule family. The encoded protein is aglycosylphosphatidylinositol-anchored glycoprotein that functionsas an axon guidance protein in the developing and adult centralnervous system. This protein may also function as a tumorsuppressor in some cancers. Alternate splicing results in multipletranscript variants.
Nohra, R., et al. Genes Immun. 11(4):279-293(2010)Severyn, C.J., et al. Biochem. J. 422(3):393-403(2009)Li, V.S., et al. Gastroenterology 137(1):176-187(2009)Endo, M., et al. J. Neurosci. 29(20):6649-6662(2009)Hata, K., et al. J. Cell Biol. 184(5):737-750(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.