|Other Names||Prorelaxin H2, Relaxin B chain, Relaxin A chain, RLN2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.|
|Tissue Location||Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not detected in the ovary|
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Relaxins are known endocrine and autocrine/paracrinehormones, belonging to the insulin gene superfamily. In the humanthere are three non-allelic relaxin genes, RLN1, RLN2 and RLN3.RLN1 and RLN2 share high sequence homology. The active form of theencoded protein consists of an A chain and a B chain but theircleavage sites are not definitely described yet. Relaxin isproduced by the ovary, and targets the mammalian reproductivesystem to ripen the cervix, elongate the pubic symphysis andinhibit uterine contraction. It may have additional roles inenhancing sperm motility, regulating blood pressure, controllingheart rate and releasing oxytocin and vasopressin. There are twoalternatively spliced transcript variants encoding differentisoforms described for this gene.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Vogel, I., et al. In Vivo 23(6):1005-1009(2009)Dschietzig, T., et al. Regul. Pept. 155 (1-3), 163-173 (2009) :Mookerjee, I., et al. FASEB J. 23(4):1219-1229(2009)Svendsen, A.M., et al. Mol. Cell. Endocrinol. 296 (1-2), 10-17 (2008) :
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