|Other Names||Regulator of chromosome condensation, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, CHC1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1919b was selected from the C-term region of human RCC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly.|
|Cellular Location||Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis|
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Provided below are standard protocols that you may find useful for product applications.
RCC1 promotes the exchange of Ran-bound GDP by GTP. It is involved in the regulation of onset of chromosome condensation in the S phase. RCC1 binds to chromatin. The RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Patients with Raynaud disease produce antibodies that bind to RCC1.
Li, H.Y., et al., Genes Dev. 18(5):512-527 (2004).Cushman, I., et al., Mol. Biol. Cell 15(1):245-255 (2004).Nemergut, M.E., et al., J. Biol. Chem. 277(20):17385-17388 (2002).Moore, W., et al., Curr. Biol. 12(16):1442-1447 (2002).Nemergut, M.E., et al., Science 292(5521):1540-1543 (2001).
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