|Other Names||Protein-glutamine gamma-glutamyltransferase 5, Transglutaminase X, TG(X), TGX, TGase X, Transglutaminase-5, TGase-5, TGM5, TGMX|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.|
|Cellular Location||Cytoplasm. Note=Associated with intermediate filaments|
|Tissue Location||Expressed in foreskin keratinocytes.|
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This gene encodes a member of the transglutaminase family.The encoded protein catalyzes formation of protein cross-linksbetween glutamine and lysine residues, often resulting instabilization of protein assemblies. This reaction is calciumdependent. Mutations in this gene have been associated with acralpeeling skin syndrome.
Kiritsi, D., et al. J. Invest. Dermatol. 130(6):1741-1746(2010)Kharfi, M., et al. J. Invest. Dermatol. 129(10):2512-2515(2009)Broderick, P., et al. Cancer Res. 69(16):6633-6641(2009)Pietroni, V., et al. J. Invest. Dermatol. 128(12):2760-2766(2008)Cassidy, A.J., et al. Am. J. Hum. Genet. 77(6):909-917(2005)
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