|Other Names||Fructose-2, 6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator, TIGAR, C12orf5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is regulated as part of the p53 tumor suppressorpathway and encodes a protein with sequence similarity to thebisphosphate domain of the glycolytic enzyme that degradesfructose-2,6-bisphosphate. The protein functions by blockingglycolysis and directing the pathway into the pentose phosphateshunt. Expression of this protein also protects cells from DNAdamaging reactive oxygen species and provides some protection fromDNA damage-induced apoptosis. The 12p13.32 region that includesthis gene is paralogous to the 11q13.3 region. [provided byRefSeq].
Bensaad, K., et al. EMBO J. 28(19):3015-3026(2009)Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)Lopez-Guerra, M., et al. Haematologica 93(12):1843-1851(2008)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Bensaad, K., et al. Cell 126(1):107-120(2006)
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