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SLC25A21 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BQT8
Clone Names 100422045
Additional Information
Gene ID 89874
Other Names Mitochondrial 2-oxodicarboxylate carrier, Solute carrier family 25 member 21, SLC25A21, ODC
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC25A21
Synonyms ODC
Function Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism (PubMed:11083877). Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2- aminohexanedioate), oxaloacetate, and citrate (PubMed:11083877). Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle (Probable).
Cellular Location Mitochondrion inner membrane; Multi-pass membrane protein
Tissue Location Expressed in placenta, gall bladder and colon.
Research Areas
Citations (0)
citation

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Background

SLC25A21 is a homolog of the S. cerevisiae ODC proteins,mitochondrial carriers that transport C5-C7 oxodicarboxylatesacross inner mitochondrial membranes. One of the speciestransported by ODC is 2-oxoadipate, a common intermediate in thecatabolism of lysine, tryptophan, and hydroxylysine in mammals.Within mitochondria, 2-oxoadipate is converted intoacetyl-CoA.

References

Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Trynka, G., et al. Gut 58(8):1078-1083(2009)Fiermonte, G., et al. J. Biol. Chem. 276(11):8225-8230(2001)

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$ 277.78
Cat# BP19237a
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