SLC25A21 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BQT8 |
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Clone Names | 100422045 |
Gene ID | 89874 |
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Other Names | Mitochondrial 2-oxodicarboxylate carrier, Solute carrier family 25 member 21, SLC25A21, ODC |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC25A21 |
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Synonyms | ODC |
Function | Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism (PubMed:11083877). Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2- aminohexanedioate), oxaloacetate, and citrate (PubMed:11083877). Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle (Probable). |
Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
Tissue Location | Expressed in placenta, gall bladder and colon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC25A21 is a homolog of the S. cerevisiae ODC proteins,mitochondrial carriers that transport C5-C7 oxodicarboxylatesacross inner mitochondrial membranes. One of the speciestransported by ODC is 2-oxoadipate, a common intermediate in thecatabolism of lysine, tryptophan, and hydroxylysine in mammals.Within mitochondria, 2-oxoadipate is converted intoacetyl-CoA.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Trynka, G., et al. Gut 58(8):1078-1083(2009)Fiermonte, G., et al. J. Biol. Chem. 276(11):8225-8230(2001)
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