|Other Names||Mitochondrial 2-oxodicarboxylate carrier, Solute carrier family 25 member 21, SLC25A21, ODC|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
SLC25A21 is a homolog of the S. cerevisiae ODC proteins,mitochondrial carriers that transport C5-C7 oxodicarboxylatesacross inner mitochondrial membranes. One of the speciestransported by ODC is 2-oxoadipate, a common intermediate in thecatabolism of lysine, tryptophan, and hydroxylysine in mammals.Within mitochondria, 2-oxoadipate is converted intoacetyl-CoA.
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Trynka, G., et al. Gut 58(8):1078-1083(2009)Fiermonte, G., et al. J. Biol. Chem. 276(11):8225-8230(2001)
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