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ULK2 Antibody (Center S323) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8IYT8
Clone Names 120106016
Peptide ID 120106016
Additional Information
Gene ID 9706
Other Names Serine/threonine-protein kinase ULK2, Unc-51-like kinase 2, ULK2, KIAA0623
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ULK2
Synonyms KIAA0623
Function Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
Cellular Location Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre- autophagosomal membrane
Research Areas
Citations (0)

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This gene encodes a protein that is similar to aserine/threonine kinase in C. elegans which is involved in axonalelongation. The structure of this protein is similar to the C.elegans protein in that both proteins have an N-terminal kinasedomain, a central proline/serine rich (PS) domain, and a C-terminal(C) domain. The gene is located within the Smith-Magenis syndromeregion on chromosome 17. Alternatively spliced transcript variantsencoding the same protein have been identified. [provided byRefSeq].


Rose, J. Phd, et al. Mol. Med. (2010) In press :Jung, C.H., et al. Mol. Biol. Cell 20(7):1992-2003(2009)Stelzl, U., et al. Cell 122(6):957-968(2005)Tomoda, T., et al. Genes Dev. 18(5):541-558(2004)Yan, J., et al. Oncogene 18(43):5850-5859(1999)

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$ 80.00
Cat# BP19251c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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