|Other Names||26S proteasome non-ATPase regulatory subunit 14, 3419-, 26S proteasome regulatory subunit RPN11, 26S proteasome-associated PAD1 homolog 1, PSMD14, POH1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.|
|Tissue Location||Widely expressed. Highest levels in heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
PSMD14 is a component of the 26S proteasome, amultiprotein complex that degrades proteins targeted fordestruction by the ubiquitin pathway (Spataro et al., 1997 [PubMed9374539]).
Byrne, A., et al. Exp. Cell Res. 316(2):258-271(2010)Ma, Z., et al. Pediatr Int 51(5):732-735(2009)Cooper, E.M., et al. EMBO J. 28(6):621-631(2009)Koulich, E., et al. Mol. Biol. Cell 19(3):1072-1082(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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