|Other Names||Quinone oxidoreductase PIG3, 1---, Tumor protein p53-inducible protein 3, p53-induced gene 3 protein, TP53I3, PIG3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).|
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The protein encoded by this gene is similar tooxidoreductases, which are enzymes involved in cellular responsesto oxidative stresses and irradiation. This gene is induced by thetumor suppressor p53 and is thought to be involved in p53-mediatedcell death. It contains a p53 consensus binding site in itspromoter region and a downstream pentanucleotide microsatellitesequence. P53 has been shown to transcriptionally activate thisgene by interacting with the downstream pentanucleotidemicrosatellite sequence. The microsatellite is polymorphic, with avarying number of pentanucleotide repeats directly correlated withthe extent of transcriptional activation by p53. It has beensuggested that the microsatellite polymorphism may be associatedwith differential susceptibility to cancer. At least two transcriptvariants encoding the same protein have been found for this gene.
Kotsinas, A., et al. Oncogene 29 (37), 5220 (2010) :Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Lee, J.H., et al. Oncogene 29(10):1431-1450(2010)Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
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