|Other Names||Translation initiation factor eIF-2B subunit gamma, eIF-2B GDP-GTP exchange factor subunit gamma, EIF2B3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1930a was selected from the C-term region of human EIF2B3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|
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Provided below are standard protocols that you may find useful for product applications.
EIF2B3 catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutations in each of the five subunits of translation initiation factor eIF2B, including subunit 3, can cause leukoencephalopathy with vanishing white matter. EIF2B3 has also been identified as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation.
van der Knaap, M.S., et al., Ann. Neurol. 51(2):264-270 (2002).Kruger, M., et al., Proc. Natl. Acad. Sci. U.S.A. 97(15):8566-8571 (2000).Gomez, E., et al., Mol. Cell. Biol. 20(11):3965-3976 (2000).
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