|Other Names||Cleavage and polyadenylation specificity factor subunit 2, Cleavage and polyadenylation specificity factor 100 kDa subunit, CPSF 100 kDa subunit, CPSF2, CPSF100, KIAA1367|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1933a was selected from the Center region of human CPSF2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing.|
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Provided below are standard protocols that you may find useful for product applications.
CPSF2 is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition.
Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004).Hodgman, R., et al., Development 128(14):2815-2822 (2001).de Vries, H., et al., EMBO J. 19(21):5895-5904 (2000).Monsalve, M., et al., Mol. Cell 6(2):307-316 (2000).Takagaki, Y., et al., Mol. Cell. Biol. 20(5):1515-1525 (2000).
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