|Other Names||N-myc-interactor, Nmi, N-myc and STAT interactor, NMI|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.|
|Tissue Location||Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver|
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NMYC interactor (NMI) encodes a protein that interactswith NMYC and CMYC (two members of the oncogene Myc family), andother transcription factors containing a Zip, HLH, or HLH-Zipmotif. The NMI protein also interacts with all STATs except STAT2and augments STAT-mediated transcription in response to cytokinesIL2 and IFN-gamma. The NMI mRNA has low expression levels in allhuman fetal and adult tissues tested except brain and has highexpression in cancer cell line-myeloid leukemias. [provided byRefSeq].
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Fillmore, R.A., et al. Int. J. Cancer 125(3):556-564(2009)Quaye, L., et al. Br. J. Cancer 100(6):993-1001(2009)Vega, A., et al. Gynecol. Oncol. 112(1):210-214(2009)Quaye, L., et al. Clin. Cancer Res. 14(18):5833-5839(2008)
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