|Other Names||Cholecystokinin receptor type A, CCK-A receptor, CCK-AR, Cholecystokinin-1 receptor, CCK1-R, CCKAR, CCKRA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a G-protein coupled receptor that bindsnon-sulfated members of the cholecystokinin (CCK) family of peptidehormones. This receptor is a major physiologic mediator ofpancreatic enzyme secretion and smooth muscle contraction of thegallbladder and stomach. In the central and peripheral nervoussystem this receptor regulates satiety and the release ofbeta-endorphin and dopamine.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Cong, P., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (3), G742-G750 (2010) :Tiwari, A.K., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry (2010) In press :Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Park, S.Y., et al. J Neurogastroenterol Motil 16(1):71-76(2010)
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