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NEIL3 Antibody(Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q8TAT5
Clone Names 100528310
Peptide ID 100528310
Additional Information
Gene ID 55247
Other Names Endonuclease 8-like 3, 322-, DNA glycosylase FPG2, DNA glycosylase/AP lyase Neil3, Endonuclease VIII-like 3, Nei-like protein 3, NEIL3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEIL3
Function DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5- OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.
Cellular Location Nucleus.
Tissue Location Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts.
Research Areas
Citations (0)

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NEIL3 belongs to a class of DNA glycosylases homologous tothe bacterial Fpg/Nei family. These glycosylases initiate the firststep in base excision repair by cleaving bases damaged by reactiveoxygen species and introducing a DNA strand break via theassociated lyase reaction (Bandaru et al., 2002 [PubMed12509226]).


Krokeide, S.Z., et al. Protein Expr. Purif. 65(2):160-164(2009)Takao, M., et al. Genes Cells 14(2):261-270(2009)Dallosso, A.R., et al. Gut 57(9):1252-1255(2008)Bethke, L., et al. J. Natl. Cancer Inst. 100(4):270-276(2008)Newton-Cheh, C., et al. BMC Med. Genet. 8 SUPPL 1, S7 (2007) :

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$ 80.00
Cat# BP19397c
(40 western blots)
Availability: In Stock
Bulk Size
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