|Other Names||Cyclin-D1-binding protein 1, Grap2 and cyclin-D-interacting protein, Human homolog of Maid, CCNDBP1, DIP1, GCIP, HHM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DIP1, GCIP, HHM|
|Function||May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Ubiquitously expressed. Expression is down- regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.|
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This gene was identified by the interaction of its geneproduct with Grap2, a leukocyte-specific adaptor protein importantfor immune cell signaling. The protein encoded by this gene wasshown to interact with cyclin D. Transfection of this gene in cellswas reported to reduce the phosphorylation of Rb gene product bycyclin D-dependent protein kinase, and inhibit E2F1-mediatedtranscription activity. This protein was also found to interactwith helix-loop-helix protein E12 and is thought to be a negativeregulator of liver-specific gene expression. Several alternativelyspliced variants have been found for this gene. [provided byRefSeq].
Lee, I., et al. Cancer Res. 70(11):4357-4365(2010)Seto, A., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (PT 1), 21-24 (2009) :Ikushima, H., et al. EMBO J. 27(22):2955-2965(2008)Chen, W.C., et al. Histopathology 53(5):554-560(2008)Chang, T.W., et al. Oncogene 27(3):332-338(2008)
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