|Other Names||Probable ergosterol biosynthetic protein 28, C14orf1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitous; strongly expressed in testis and some cancer cell lines|
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Provided below are standard protocols that you may find useful for product applications.
ERG28 (Probable ergosterol biosynthetic protein 28) has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. ERG28 may also be responsible for facilitating their interaction. The ERG28 encoded protein, Erg28p, interacts with both the sterol C4 demethylation enzyme complex as well as the late biosynthetic protein, the C24 sterol methyltransferase (Erg6p). ERG28 acts as a scaffold to tether ERG27 and other 4,4 demethylation related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. ERG28 interacts with ERG25, ERG26 and ERG27. It also interacts with ERG1, ERG3, ERG5, ERG6 and ERG11.
Stelzl, U., et al. Cell 122(6):957-968(2005)Schirmer, E.C., et al. Science 301(5638):1380-1382(2003)Heilig, R., et al. Nature 421(6923):601-607(2003)Veitia, R.A., et al. J. Genet. 80(1):17-21(2001)Gachotte, D., et al. J. Lipid Res. 42(1):150-154(2001)
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