|Other Names||Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, GM-CSF-R-alpha, GMCSFR-alpha, GMR-alpha, CDw116, CD116, CSF2RA, CSF2R, CSF2RY|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Isoform 4: Secreted.|
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The protein encoded by this gene is the alpha subunit ofthe heterodimeric receptor for colony stimulating factor 2, acytokine which controls the production, differentiation, andfunction of granulocytes and macrophages. The encoded protein is amember of the cytokine family of receptors. This gene is found inthe pseudoautosomal region (PAR) of the X and Y chromosomes.Multiple transcript variants encoding different isoforms have beenfound for this gene, with some of the isoforms being membrane-boundand others being soluble.
Mirza, S., et al. Biochem. J. 426(3):307-317(2010)Sun, S., et al. Brain Res. 1268, 13-16 (2009) :Suzuki, T., et al. J. Exp. Med. 205(12):2703-2710(2008)Martinez-Moczygemba, M., et al. J. Exp. Med. 205(12):2711-2716(2008)Hansen, G., et al. Cell 134(3):496-507(2008)
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